Chilean neurorights legislation and its relevance for mental health: Criticisms and outlook / La legislación chilena sobre neuroderechos y su relevancia para la salud mental: Críticas y perspectivas

Abstract Background Recently, the academic world has established a series of reconfigurations of emerging human rights, in order to safeguard the mental integrity of people exposed to neurotechnologies. The recommendations of different stakeholders and a literature review support regulation of these technologies. There are different proposals for regulation, some in soft law and others in objective law. The type of regulation chosen can have repercussions on clinical practice, research, and public policy. The constitutional enactment of neurorights in Chile has been criticized in the academic fields of neuroethics and law as having potential negative effects on mental health research. Objective To analyze in light of the available literature whether the construction of neurorights could create ethical conflicts in the field of mental health, or if it could offer protection against the disruptive use of various neurotechnologies. Method This analysis included a narrative review of studies included in the PsycInfo, Springer, JSTOR, Medline, Scopus, PubMed, CINALH, and Web of Science databases, without restrictions on language or year of publication. Results The enactment of neurorights as hard law is found not to be detrimental to the field of mental health. Discussion and conclusion This article argues that the regulation of neurorights does not threaten the framework of an ecosystem that uses neurotechnologies. On the contrary, such regulation offers protections to people within the complex system of neurotechnologies.

Resumen Antecedentes Recientemente, el mundo académico ha establecido una serie de reconfiguraciones de derechos humanos emergentes, con el fin de salvaguardar la indemnidad mental de las personas expuestas a las neurotecnologías. Las recomendaciones de las diferentes partes interesadas y de una revisión bibliográfica son la regulación de estas. Existen diferentes ejemplos de regulación, algunos de derecho blando y otros de derecho objetivo. El tipo de regulación puede tener repercusiones en la práctica clínica, la investigación y las políticas públicas de una comunidad. La consagración constitucional chilena de los neuroderechos ha sido criticada desde el mundo académico de la neuroética y también desde el derecho argumentándose que podría ser negativa para la investigación en salud mental. Objetivo Analizar a la luz de la literatura disponible si la constitucionalización de los neuroderechos es éticamente conflictiva en el campo de la salud mental o más bien la protege frente del uso disruptivo de diversas neurotecnologías. Método Revisión narrativa de estudios incluidos en las siguientes bases de datos (PsycInfo, Springer, JSTOR, Medline, Scopus, PubMed, CINALH y Web of Science) sin restricciones de idioma o año de publicación. Resultados No se considera que la consagración de los neuroderechos como hard law sea perjudicial en el ámbito de la salud mental. Discusión y conclusión Se discute si los neuroderechos son una regulación amenazante en el marco de un ecosistema que utiliza neurotecnologías. Se concluye que, a pesar de las críticas, no lo es, sino que favorece la protección de las personas del uso inapropiado de neurotecnologías.

Las revistas científicas relegadas: el arduo camino de las revistas peruanas

Este artículo tiene como objetivo examinar la valoración que se les da a las revistas científicas peruanas según los reglamentos actuales relacionados con ciencia y tecnología, lo que lleva a que existan clasificaciones de revistas y que las personas autoras se interesen en publicar en función del puntaje para el desarrollo de la carrera académica y de investigación. Metodológicamente se revisaron los reglamentos vigentes de dicha clasificación y calificación de investigadores, así como las características que debe tener una revista para incluirse en los mismos, para luego examinar el portal de ISSN y comparar la lista de revistas científicas registradas de manera que pueda observarse qué porcentaje de esas revistas se consideran para las clasificaciones vigentes. Se concluye que existe un alto porcentaje de revistas peruanas relegadas o fuera del sistema de clasificación, lo que hace que el proceso de crecimiento se vuelva complicado, haciendo el camino de la indexación más tormentoso para los equipos editoriales. Es necesario trabajar por el desarrollo de ciencia nueva y eso involucra dar la oportunidad a estas revistas para seguir avanzando en los procesos de gestión editorial.

This article aims to examine the valuation given to Peruvian scientific journals according to current regulations related to science and technology, which leads to the existence of journal classifications and that authors are interested in publishing based on the score for academic and research career development. Methodologically, the current regulations of said classification and qualification of researchers will be reviewed, as well as the characteristics that a journal must have to be included in them, to later examine the ISSN portal and compare the list of registered scientific journals so that it can be observed which percentage of those journals are considered for current rankings. It is concluded that there is a high percentage of peruvian journals relegated or outside the classification system, which makes the growth process complicated, making the path of indexing harder for editorial teams. It is necessary to work for the development of new science and that involves giving these journals the opportunity to continue advancing in editorial management processes.

Information Gain By People Through Media Related To Laws Governing In Stock Market

The media is a snapshot of our culture, depicting what and how society functions. The only medium that aids in informing people is media, whether it is written, electronic, or on the internet. It also aids in entertaining the public, as well as educating and informing people about current events. The media has evolved into our society's voice.While most people have no direct information about stock market, the media has a significant impact on public attitudes and actions. The stock market is a significant participant in the financial sector, which is made up of both small and large businesses. Therefore, it becomes important to control the markets in order to protect investors' interests as well as those of the business sector. Additionally, the stock market is exposed, which hurts the public's overall interest. As a result, a number of laws have been enacted to safeguard investors and guarantee a just exchange of business ownership in free markets. Purpose: The majority of people have erroneous perceptions of laws related to stock market. They are informed of stock market through the media. The aim of this paper is to give information about laws and regulations through media to a society. Because most individuals are unaware of the laws and regulations pertaining to the stock market. ThroughNeed: media people are aware about laws and regulations of stock market.Methodology: The study based on secondary data.

Investigation on public satisfaction with the enforcement of tobacco control regulations based on questionnaire survey —— a case study of Tianjin / 公共卫生与预防医学

Objective To analyze the residents' satisfaction with the enforcement of The Regulations of Tianjin Municipality on Smoking Control in Public Places (hereinafter referred to as The Regulations) and its influencing factors. Methods From November to December 2020, 16 districts of Tianjin were selected as the research site, and one street was randomly selected from each district. The accidental sampling was used to conduct a questionnaire survey on 4,160 permanent residents in Tianjin. χ2 test was used in univariate analysis and multivariate logistic regression model was used to analyze and adjust the confounding factors. The public satisfaction and its influencing factors were analyzed. Results A total of 4 022 questionnaires were collected and 2 730 were included in the study. In 2020, 89.3 percent of Tianjin residents were satisfied with the enforcement of the Regulations. Compared with residents aged 15-24, residents in other age groups were less satisfied with the enforcement of the Regulations. Compared with residents with primary school education or below, residents with high school education or bachelor's degree or the same educational level were less satisfied with the enforcement of the Regulations. Residents with chronic diseases (OR=1.885 , P<0.01) and exposure to second-hand smoke in the last 30 days (OR=1.903, P<0.01) were less satisfied with the enforcement of the Regulations, while those who supported the Regulations (OR=0.511, P<0.01) and residents who had been exposed to public service advertisements on tobacco control in the last 30 days (OR=0.043, P<0.01) were more satisfied with the enforcement of the Regulations. Conclusion The residents of Tianjin are highly satisfied with the enforcement of the Regulations. Age, education background, support for the Regulations, chronic disease, exposure to secondhand smoke in the last 30 days and exposure to public service advertisements in the last 30 days are the main influencing factors of satisfaction with the enforcement of tobacco control regulations.

RDFization of Interview Forms for Effective Use of Pharmaceutical Documents / 医薬品情報学

Objective: Pharmaceutical documents such as the common technical document, package inserts (PIs), and interview forms (IFs) are available at the website of the Pharmaceuticals and Medical Devices Agency. However, because these documents were created with an emphasis on human readability in paper form, it is difficult to use the information included and interoperate these documents with computers. Using IFs, we will investigate how to structure pharmaceutical documents in the AI era to achieve both human and machine readability.Design/Methods: The IFs of arbitrary selected ten drugs were structured into Resource Description Framework (RDF) according to the Drug Interview Form Description Guidelines 2018 (updated version in 2019). The data were manually extracted from the IFs and entered into a spreadsheet before being converted to RDF by a written script. The PIs were converted to RDF in addition to the IFs. To examine the linkage with external databases, IDs in ChEMBL, which is a manually curated database of bioactive molecules with drug-like properties, were embedded in the RDF.Results: We demonstrated that the conversion of IFs and PIs into RDF makes it possible to easily retrieve the corresponding part of the PIs cited in the IFs. Furthermore, we quickly obtained the relevant data from ChEMBL, demonstrating the feasibility of linking IFs with an external database. Our attempt to RDFization of IFs is expected to encourage the development of web applications for healthcare professionals and the development of datasets for AI development.Conclusion: We could easily interoperate IFs with other pharmaceutical documents and an external database by converting IFs into RDF following the description guidelines. However, problems such as how to deal with items that were not described in the description guidelines were indicated. We hope that discussions will grow based on this effort and that related industries will move toward accomplishing effective use of these documents.

Presentación: Regulaciones sociales del género, la sexualidad y la edad: reflexiones sobre políticas, prácticas y discursos desde una perspectiva regional / Apresentação: Regulações sociais de gênero, sexualidade e idade: reflexões sobre políticas, práticas e discursos em perspectiva regional / Presentation: Social regulations of gender, sexuality and age: reflections on policies, practices and discourses from a regional perspective

Resumen El presente texto tiene como objetivo la presentación del dossier "Regulaciones sociales del género, la sexualidad y la edad: reflexiones sobre políticas, prácticas y discursos desde una perspectiva regional". El dossier reúne trabajos académicos que, desde distintas disciplinas y perspectivas conceptuales, reflexionan críticamente acerca de las formas en que el género y la sexualidad, en intersección con la edad, la clase social y la raza, son procesados y regulados socialmente en contextos de desigualdad. Sus contribuciones permiten también reflexionar sobre tales regulaciones como configuraciones sociales, culturales y materiales complejas, conflictivas y disputadas con variabilidad histórica que se rearticulan a la luz de procesos globales de gobierno.

Resumo O objetivo do texto é apresentar o dossiê "Regulações sociais de gênero, sexualidade e idade: reflexões sobre políticas, práticas e discursos em perspectiva regional". O dossier reúne trabalhos académicos que, a partir de diferentes disciplinas e perspectivas conceituais, refletem criticamente sobre os modos como o gênero e a sexualidade, em intersecção com idade, classe social e raça, são e socialmente regulados em contextos de desigualdade. As contribuições dos artigos nos permitem refletir sobre as regulações como configurações sociais, culturais e materiais complexas, conflituosas e contestadas, com variabilidade histórica, que são rearticuladas à luz de processos globais de governança.

Abstract The aim of this text is to present the dossier "Social regulations of gender, sexuality and age: reflections on policies, practices and discourses from a regional perspective". The dossier brings together academic works that, from different disciplines and conceptual perspectives, critically reflect on the ways in which gender and sexuality, in intersection with age, social class and race, are processed and socially regulated in contexts of inequality. Their contributions also allow us to reflect on such regulations as complex, conflicting and contested social, cultural and material configurations with historical variability that are re-articulated in the light of global processes of governance.

Gerenciamento tensionado: o sistema de vigilância em saúde e a resposta à pandemia da covid-19 no Brasil / Management in tension: the Brazilian public health surveillance system and its response to the covid-19 pandemic

Resumo O artigo aborda a resposta do governo brasileiro à pandemia da covid-19, enfatizando o sistema de vigilância em saúde e de inteligência epidemiológica. Retoma a evolução da vigilância em resposta às normas do Regulamento Sanitário Internacional, no contexto da saúde global. Analisa os atos do Executivo publicados no Diário Oficial da União e se detém nos atores e grupos formados para o enfrentamento da pandemia da covid-19 de janeiro de 2020 até março de 2022. Parte da premissa de que a inteligência epidemiológica deve estar a serviço da saúde pública. Constata-se que certo tensionamento burocrático e a transferência de protagonismo entre grupos marcam o desmonte dos mecanismos de inteligência.

Abstract This article addresses the Brazilian government's response to the covid-19 pandemic, particularly the public health surveillance and epidemic intelligence system. It traces the evolution of disease surveillance as a response to the International Health Regulations in the context of global health. Executive orders published in the official gazette, Diário Oficial da União, are analyzed, as well as the actors and groups formed to tackle the pandemic between January 2020 and March 2022. The founding assumption is that epidemic intelligence must be placed at the service of public health. Bureaucratic tension and changes in protagonism among different groups can be observed as these intelligence mechanisms were dismantled.

Determinants of disordered eating behaviors: Body mass index, emotional eating, dietary restriction, and motives for eating palatable foods / Determinantes de comportamentos alimentares desordenados: índice de massa corporal, alimentação emocional, restrição alimentar e motivos para comer alimentos palatáveis

ABSTRACT Objective: The study aimed to investigate the relationships between body mass index, reasons for consuming palatable foods, emotional eating, cognitive dietary restraint, and disordered eating behaviors in young adults. Methods: This study was conducted with 800 young adults, in Ankara, Türkiye. A questionnaire consisting of questions about socio-demographic characteristics, health status, and instruments including Eating Attitudes Test-26, Emotional Appetite Questionnaire, Palatable Eating Motives Scale, and The Three-Factor Eating Questionnaire were applied through face-to-face interviews. Results: According to the Eating Attitudes Test-26, 17.2% of males and 27.7% of females were at risk for disordered eating behaviors (χ2=9.750, p=0.002). The mean scores of the Three-Factor Eating Questionnaire-emotional eating, cognitive restraint subscales, and the positive and negative scores of the Emotional Appetite Questionnaire were higher in males than in females (p<0.05). The mean scores of the Palatable Eating Motives Scale-coping and reward enhancement motives were higher in females, while the mean score for the conformity motives was significantly higher in males. Body mass index, Three-Factor Eating Questionnaire-cognitive restraint subscale, Emotional Appetite Questionnaire-negative, and PEMS-conformity motives were found for predictors for Eating Attitudes Test-26 (all p<0.05). Conclusion: The results showed a high tendency for emotional eating, consumption of palatable foods, and cognitive dietary restraint in young adults, and these factors were considered determinants for eating disorders.

RESUMO Objetivo: O objetivo do estudo foi investigar as relações entre o índice de massa corporal, as razões para consumir alimentos palatáveis, o comer emocional, a restrição alimentar cognitiva e os comportamentos de desordem alimentar em jovens adultos. Métodos: Este estudo foi realizado com 800 jovens adultos, em Ancara, na Turquia. Foi aplicado um questionário composto por perguntas sobre características sociodemográficas, estado de saúde e instrumentos, incluindo o Eating Attitudes Test-26, o Emotional Appetite Questionnaire, a Palatable Eating Motives Scale e o The Three-Fator Eating Questionnaire, através de entrevistas presenciais. Resultados: De acordo com o Eating Attitudes Test-26, 17,2% dos homens e 27,7% das mulheres estavam em risco de desenvolver comportamentos alimentares desordenados (χ2=9,750, p=0,002). As pontuações médias do Three-Fator Eating Questionnaire-emotional eating, as subescalas de restrição cognitiva e as pontuações positivas e negativas do Emotional Appetite Questionnaire foram mais elevadas no sexo masculino do que no feminino (p<0,05). As pontuações médias da Palatable Eating Motives Scale - motivos de coping e de aumento da recompensa - foram mais elevadas no sexo feminino, enquanto a pontuação média para os motivos de conformidade foi significativamente mais elevada no sexo masculino. O índice de massa corporal, o Three-Fator Eating Questionnaire-subescala de contenção cognitiva, o Emotional Appetite Questionnaire-negativo e o PEMS-motores de conformidade foram encontrados como preditores do Eating Attitudes Test-26 (todos p<0,05). Conclusão: Os resultados mostraram uma elevada tendência para a alimentação emocional, o consumo de alimentos palatáveis e a restrição alimentar cognitiva em adultos jovens, sendo estes factores considerados determinantes para as perturbações alimentares.

Covid-19 na América Latina: desigualdades e capacidades de resposta dos sistemas de saúde a emergências sanitárias / COVID-19 in Latin America: inequalities and response capacity of health systems to health emergencies / COVID-19 en América Latina: desigualdades y capacidad de respuesta de los sistemas de salud ante emergencias de salud

RESUMO Objetivo. Identificar correlações entre a covid-19, características demográficas e socioeconômicas e capacidade dos sistemas de saúde latino-americanos para resposta a emergências sanitárias. Método. Realizou-se um estudo ecológico, utilizando dados secundários de 20 países latino-americanos relativos a incidência, mortalidade, testagem e cobertura vacinal para covid-19 no período de 2020 a 2021, assim como informações demográficas e socioeconômicas. A preparação dos países para responder a emergências sanitárias foi explorada a partir do Relatório Anual de Autoavaliação dos Estados Partes da Organização Mundial da Saúde de 2019 sobre a implementação do Regulamento Sanitário Internacional (RSI). Realizaramse análises estatísticas por meio do teste de correlação de Spearman (rho). Resultados. Observou-se correlação positiva alta do produto interno bruto per capita e do índice de desenvolvimento humano com incidência de covid-19, testagem e cobertura vacinal; e entre proporção da população idosa e cobertura vacinal. Não foram identificadas correlações entre os indicadores da covid-19 e as capacidades prévias de implementação do RSI. Conclusões. A ausência de correlação entre indicadores relativos à covid-19 e a capacidade de implementação do RSI pode estar relacionada a limites dos indicadores utilizados ou da ferramenta de acompanhamento do RSI como instrumento indutor da preparação dos países para enfrentamento de emergências sanitárias. Os resultados sugerem a importância de condicionantes estruturais e a necessidade de estudos longitudinais, comparativos e qualitativos para compreender os fatores que influenciaram a resposta dos países à covid-19.

ABSTRACT Objective. To identify correlations between COVID-19, demographic and socioeconomic characteristics, and the capacity of Latin American health systems to respond to health emergencies. Method. An ecological study was performed using secondary data from 20 Latin American countries regarding incidence, mortality, testing and vaccination coverage for covid-19 from 2020 to 2021 as well as demographic and socioeconomic indicators. The preparedness of countries to respond to health emergencies was explored based on the 2019 State Party Self-Assessment Annual Report on the implementation of the International Health Regulations (IHR). Statistical analyses were performed using the Spearman correlation test (rho). Results. A high positive correlation was noted between gross domestic product per capita and the human development index with the incidence of COVID-19, testing, and vaccination coverage; and between the proportion of elderly population and vaccination coverage. No correlations were identified between the covid-19 indicators and previous IHR implementation capacities. Conclusions. The lack of correlation between indicators related to COVID-19 and the ability to implement the IHR may reflect limitations of the indicators used or of the IHR monitoring tool as an instrument that induces the preparedness of countries to face health emergencies. The results suggest the importance of structural conditioning factors and the need for longitudinal, comparative, and qualitative studies to understand the factors that influenced the response of countries to COVID-19.

RESUMEN Objetivo. Determinar las posibles correlaciones entre la COVID-19, las características demográficas y socioeconómicas, y la capacidad de los sistemas de salud latinoamericanos para responder a emergencias de salud. Método. Se realizó un estudio ecológico con datos secundarios de 20 países latinoamericanos sobre la incidencia, la mortalidad, las pruebas y la cobertura de vacunación relativas a la COVID-19 en el período 2020-2021, y con información demográfica y socioeconómica. Se exploró la preparación de los países para responder a emergencias de salud a partir del Informe Anual de Autoevaluación de los Estados Miembros de la Organización Mundial de la Salud del 2019 sobre la implementación del Reglamento Sanitario Internacional (RSI). Los análisis estadísticos se realizaron con la prueba de correlación (ro) de Spearman. Resultados. Se observó una alta correlación positiva del producto interno bruto per cápita y del índice de desarrollo humano con la incidencia, las pruebas y la cobertura de vacunación respecto a la COVID-19, así como de la proporción de personas mayores en la población con la cobertura de vacunación. No se observó ninguna correlación entre los indicadores de COVID-19 y la capacidad previa de implementación del RSI. Conclusiones. La falta de correlación entre los indicadores relativos a la COVID-19 y la capacidad de implementación del RSI puede deberse a limitaciones de los indicadores utilizados o del mecanismo de seguimiento del RSI como instrumento inductor de la preparación de los países para enfrentar emergencias de salud. Los resultados sugieren la importancia de los factores condicionantes estructurales y la necesidad de realizar estudios longitudinales, comparativos y cualitativos para determinar los factores que influyeron en la respuesta de los países a la COVID-19.

Aplicabilidad del componente lactancia materna de la normativa Establecimientos de Salud Amigos de la Madre y del Niño

Introducción: Dentro de los objetivos estratégicos del Plan de Desarrollo y Ordenamiento Territorial de la provincia de Esmeraldas, Ecuador, se plantea generar acciones afirmativas para garantizar el acceso a la salud y la promoción de derechos y deberes a favor de la población; sin embargo, apenas inicia con la normativa sanitaria para la certificación de ESAMyN. Objetivo: Describir la aplicabilidad del componente lactancia materna normativa del Establecimientos de Salud Amigos de la Madre y del Niño en el Centro de Salud Tipo C Las Palmas de Esmeraldas, Ecuador. Método: Se realizó un estudio bajo una modalidad mixta, donde se aplicó una encuesta sobre dicha normativa a 56 profesionales de la salud Resultados: El 75 % del personal tiene conocimiento sobre la normativa ESAMYN pero se identificó que el personal no aplica la normativa vigente, pues solo el 26,79 % sabe sobre su composición, solo el 43 % respondió correctamente el objetivo de la misma y el 29 % a quién va dirigida. Por otra parte, el 57 % del personal de Enfermería conoce sobre cuántas pruebas son necesarias a una mujer durante el embarazo, parto y posparto; y el 41 % manifestó conocer qué es el acompañamiento familiar durante el parto. Conclusiones: El presente estudio aporta una estrategia para mejorar el servicio de salud hacia las madres y sus hijos recién nacidos sobre la normativa de ESAMYN, lo que contribuye a la disminución de brechas intersectoriales y regionales.

Introduction: Within the strategic objectives of the Territorial Development and Planning Plan of the province of Esmeraldas, Ecuador, it is proposed to generate affirmative actions to guarantee access to health and the promotion of rights and duties in favor of the population; However, it is just beginning with the health regulations for ESAMyN certification. Objective: To describe the applicability of the normative breastfeeding component of the Mother and Child Friendly Health Establishments in the Type C Health Center Las Palmas de Esmeraldas, Ecuador. Method: A study was carried out under a mixed modality, where a survey about said regulations was applied to 56 health professionals. Results: 75% of the staff have knowledge about the ESAMYN regulations but it was identified that the staff does not apply the current regulations. since only 26.79% know about its composition, only 43% correctly answered its objective and 29% to whom it is directed. On the other hand, 57% of Nursing staff know how many tests are necessary for a woman during pregnancy, childbirth and postpartum; and 41% said they knew what family support during childbirth is. Conclusions: The present study provides a strategy to improve the health service for mothers and their newborn children based on the ESAMYN regulations, which contributes to the reduction of intersectoral and regional gaps.

Introdução: Dentro dos objetivos estratégicos do Plano de Desenvolvimento e Planejamento Territorial da província de Esmeraldas, Equador, propõe-se gerar ações afirmativas para garantir o acesso à saúde e a promoção de direitos e deveres em favor da população; No entanto, as regulamentações sanitárias para a certificação ESAMyN estão apenas começando. Objetivo: Descrever a aplicabilidade do componente normativo de amamentação dos Estabelecimentos de Saúde Amigos da Mãe e da Criança do Centro de Saúde Tipo C Las Palmas de Esmeraldas, Equador. Método: Foi realizado um estudo de modalidade mista, onde foi aplicado um levantamento sobre as referidas normas a 56 profissionais de saúde. Resultados: 75% dos funcionários têm conhecimento sobre as normas da ESAMYN, mas identificou-se que os funcionários não aplicam as normas vigentes. regulamentação. como apenas 26,79% conhecem sua composição, apenas 43% responderam corretamente seu objetivo e 29% a quem se destina. Por outro lado, 57% dos trabalhadores de Enfermagem sabem quantos exames são necessários para uma mulher durante a gravidez, parto e pós-parto; e 41% disseram saber o que é o apoio familiar durante o parto. Conclusões: O presente estudo fornece uma estratégia para melhorar o serviço de saúde para mães e seus filhos recém-nascidos com base na regulamentação da ESAMYN, o que contribui para a redução de lacunas intersetoriais e regionais.

COVID-19 in the Americas: the role of collaborating centers in understanding lessons and best practices in pandemic preparedness and response / COVID-19 en la Región de las Américas: papel de los centros colaboradores en la comprensión de las enseñanzas y mejores prácticas en la preparación y respuesta frente a pandemias / COVID-19 nas Américas: o papel dos centros colaboradores para entender as lições e melhores práticas de preparação e resposta a pandemias

ABSTRACT COVID-19 exposed major gaps in global, regional, state, and local responses to public health emergencies. In preparation for the WHA Special Session to consider the benefits of developing an international instrument on pandemic preparedness, the O'Neill Institute in partnership with Foundation for the National Institutes of Health convened 30 of the world's leading authorities on global health law, financing, biomedical science, implementation, and emergency response along with leaders from prominent international organizations. This meeting was followed by regional consultations convened in Latin America-Caribbean, Africa, and Southeast Asia. These high-level expert consultations generated in-depth discussions on weaknesses and persisting gaps in global pandemic preparedness and what a new international agreement might include to address them. Regional intergovernmental organizations like PAHO can work closely with related multilateral development banks to develop financial instruments that can smooth systemic economic disruption; and regional centers of research and manufacturing excellence can offer a strong front line for producing medicines and vaccines rapidly during a pandemic. With our research focused on the regional response to COVID-19 we are able to look at country responses individually and collectively to see how Latin America - Caribbean countries can capitalize and leverage their regional connections to strengthen their pandemic preparedness and response. By identifying existing gaps and examining the responses and approaches taken by PAHO, we can better understand the role of international and regional organizations and their collaborating centers in preparing and responding to pandemics.

RESUMEN La COVID-19 expuso grandes brechas en las respuestas locales, nacionales, regionales y mundiales a las emergencias de salud pública. En preparación para la reunión extraordinaria de la Asamblea Mundial de la Salud para considerar los beneficios de elaborar un instrumento internacional sobre la preparación frente a las pandemias, el Instituto O'Neill, en colaboración con la Fundación para los Institutos Nacionales de Salud, convocó a 30 de las principales autoridades mundiales en materia de derecho, financiamiento, ciencia biomédica, implementación y respuesta a emergencias de salud, así como a líderes de organizaciones internacionales prominentes. A esta reunión le siguieron consultas regionales convocadas en América Latina y el Caribe, África y el sudeste asiático. Estas consultas con expertos de alto nivel generaron debates en profundidad acerca de las debilidades y brechas persistentes en la preparación frente a las pandemias y qué podría incluirse en un nuevo acuerdo internacional sobre cómo abordarlas. Las organizaciones intergubernamentales regionales como la Organización Panamericana de la Salud pueden trabajar en estrecha colaboración con los bancos multilaterales de desarrollo relacionados para elaborar instrumentos financieros que puedan aliviar las perturbaciones económicas sistémicas; y los centros regionales de excelencia en investigación y producción pueden formar una sólida primera línea de acción para producir medicamentos y vacunas rápidamente durante una pandemia. Con esta investigación centrada en la respuesta regional a la COVID-19, podemos analizar las respuestas de los países de forma individual y colectiva para observar la manera en que América Latina y el Caribe pueden capitalizar y aprovechar sus conexiones regionales para fortalecer su preparación y respuesta frente a una pandemia. Al determinar cuáles son las brechas existentes y examinar las respuestas y los enfoques adoptados por la OPS, podemos comprender mejor el papel de las organizaciones regionales e internacionales y sus centros colaboradores en la preparación y respuesta frente a las pandemias.

RESUMO A COVID-19 expôs grandes lacunas nas respostas globais, regionais, estaduais e locais a emergências de saúde pública. Nos preparativos para a Sessão Especial da Assembleia Mundial da Saúde para avaliar os benefícios de desenvolver um instrumento internacional de preparação para pandemias, o Instituto O'Neill, em parceria com a Fundação para os Institutos Nacionais de Saúde, reuniu 30 das principais autoridades mundiais em direito sanitário global, financiamento, ciências biomédicas, implementação e resposta a emergências, além de líderes de organizações internacionais proeminentes. Essa reunião foi seguida por consultas regionais convocadas na América Latina/Caribe, na África e no sudeste da Ásia. Essas consultas com especialistas de alto nível geraram discussões minuciosas sobre os pontos fracos e as lacunas persistentes na preparação global para pandemias e o que poderia ser incluído em um novo acordo internacional para resolvê-los. Organizações intergovernamentais regionais, como a OPAS, podem trabalhar em estreita colaboração com os bancos multilaterais de desenvolvimento para desenvolver instrumentos financeiros capazes de atenuar a ruptura econômica sistêmica; por outro lado, centros regionais de excelência em pesquisa e fabricação podem oferecer uma linha de frente expressiva para a rápida produção de medicamentos e vacinas durante uma pandemia. Usando os dados da nossa pesquisa sobre a resposta regional à COVID-19, podemos analisar as respostas dos países de forma individual e coletiva para avaliar como os países da América Latina e do Caribe podem capitalizar e alavancar suas conexões regionais para fortalecer sua preparação e resposta à pandemia. Ao identificar lacunas existentes e analisar as respostas e abordagens adotadas pela OPAS, podemos compreender melhor o papel das organizações internacionais e regionais e de seus centros colaboradores na preparação e resposta a pandemias.

Points of entry dynamics: understanding the cross-border threats for Ebola virus disease and COVID-19 in Ghana using a logic model approach

Background. The influx of people across the national borders of Ghana has been of interest and concern in the public health and national security community in recent times due to the low capacity for the prevention and management of epidemics and other public health risks. Although the International Health Regulations (IHR) stipulate core public health capacities for designated border facilities such as international airports, seaports, and ground crossings, contextual factors that influence the attainment of effective public health measures and response capabilities remain understudied. Objective. To assess the relationship between contextual factors and COVID-19 procurement to help strengthen infrastructure resources for points of entry (PoE) public health surveillance functions, thereby eliminating gaps in the design, implementation, monitoring, and evaluation of pandemicrelated interventions in Ghana. Materials and Methods. This study employed a mixed-methods design, where quantitative variables were examined for relationships and effect size interactions using multiple linear regression techniques and the wild bootstrap technique. Country-level data was sourced from multiple publicly available sources using the social-ecological framework, logic model, and IHR capacity monitoring framework. The qualitative portion included triangulation with an expert panel to determine areas of convergence and divergence. Results. The most general findings were that laboratory capacity and KIA testing center positively predicted COVID-19 procurement, and public health response and airline boarding rule negatively predicted COVID-19 procurement. Conclusion. Contextual understanding of the COVID-19 pandemic and Ebola epidemic is vital for strengthening PoE mitigation measures and preventing disease importation.

Current Status and Challenges of Biological Sample Management in Clinical Trials / 中国医学伦理学

With the rapid development of clinical trials, the relevant medical research and molecular detection based on biological samples are closely related to the progress of clinical trials, making the role of biological samples in clinical trials increasingly obvious. The standardized supervision mode of biological samples is an important prerequisite for carrying out high-quality clinical trials. Although the laws and regulations related to clinical trials are becoming more and more perfect, there are still a large number of adverse events related to biological samples, which seriously affects the progress and results of clinical trials, and is one of the important challenges currently facing. Therefore, it is urgent to enhance the supervision of biological samples and improve the management methods of biological samples in clinical trials at this stage. Through in-depth discussion of the current status of biological sample management in clinical trials at home and abroad, this paper analyzed the issues existed during the supervision of biological samples, and supplemented the biological sample management methods by further combing the existing relevant laws and regulations and the Guidelines for the Ethical Management of Biological Samples in Clinical Trials, with a view to providing suggestions and ideas for optimizing the management mode of biological samples in clinical trials.

Reference and Enlightenment on the Supervision of Human Genetic Resources from Foreign Legislation / 中国医学伦理学

As an important biological resource of a country or region, human genetic resources (HGR) are increasingly attracting attention and concern from many countries internationally, and even have been elevated to the dimension of national sovereignty by many countries. As a large country with rich and diverse HGR, relevant regulatory work in China started relatively late compared to foreign countries, but has developed rapidly. However, looking around the world, there is still room for further improvement and development of domestic HGR regulation. By reviewing the regulatory legislation of HGR in some countries abroad, this paper sorted out their advanced experience and highlighted measures in detail, and summarized their deep-seated legislative guidance. A detailed analysis and evaluation were conducted from seven aspects:the advanced level of HGR legislation and the enhancement of legal effectiveness, the systematization and systematization of policies and regulations, the unification of platforms and relevant standards, the highlight of the concept of ethics and the rule of law, the strengthening of anti-discrimination protection, the special protection of major human genetic family resources and national special protection areas of HGR, and the establishment of principled consensus or agreement on HGR in international and local regions, to provide reference for the construction of regulatory policies and legal systems for HGR in China.

Research on Ethical Governance of "BRAIN Initiative" in the United States / 中国医学伦理学

With the implementation of the "BRAIN initiative" in various countries, neuroethical governance has become an important concern of the international community. After ten years of development, the "BRAIN initiative" in the United States has formed a relatively complete ethical governance system. By interpreting the strategic report of the "BRAIN initiative" in the United States, analyzing its basic framework of ethical governance, dissecting its governance practice mechanism, and conducting research from the aspects of top-level design and construction, regulatory model innovation, promoting public participation, enhancing international dialogue, and improving soft and hard regulations, this paper provided some reference and thoughts for the ethical governance of the "BRAIN initiative" in China.

Survey of knowledge acquisition for blood transfusion of medical staff in Wuwei: an underdeveloped city in western China / 中国输血杂志

【Objective】 To investigate the knowledge acquisition status for blood transfusion of transfusion related medical staff in underdeveloped cities in western China and explore its influencing factors. 【Methods】 A questionnaire consisted of blood transfusion laws and regulations, clinical blood transfusion theory and blood transfusion technology was designed, randomly distributed to medical staff and blood transfusion departmenttechnicians of 17 secondary/tertiary hospitals in Wuwei and then collected on the spot. The knowledge acquisition of blood transfusion of each group was compared using statistical description method, and its influencing factors were analyzed by multivariate logistic regression analysis. 【Results】 A total of 507 questionnaires were issued, and 498 valid questionnaires (98.22%) were collected. The scores of transfusion related laws and regulations, blood transfusion theory and blood transfusion technology of doctor group(n=158), nurse group(n=239) and transfusion technician group(n=101)were 4.56-5.97(5.06±0.73)(P<0.01) vs 4.23-5.87(4.98±1.24)(P<0.01) vs 3.71-0.78 (4.15±1.34), 3.67-5.02(4.27±1.02) vs 3.76-5.12(4.06±0.75) vs 4.71-5.98(5.16±0.64)(P<0.01) and 3.41-5.76(3.82±0.56) vs 3.78-5.24(4.01±0.56) vs 3.77-5.46(3.82±0.59). Among the seven departments, blood transfusion department(n=51) won the highest score of above three types of knowledge [4.91-5.97(5.28±0.43) vs 5.03-5.92(5.36±0.59) vs 4.39-5.77(4.97±0.79)(P<0.01) ]. Univariate logistic regression analysis showed that age, occupation, professional titles, training times and hospital grade had an impact on the degree (score) of blood transfusion knowledge acquisition (P<0.05), and multivariate unconditional logistic regression analysis indicated that training times was an important influencing factor(P<0.01). 【Conclusion】 This survey revealed that the level of knowledge acquisition for blood transfusion among medical staff in Wuwei is generally low, and there is a significant difference between staff from hospitals of different grade and different departments. It is urgent to strengthen the training of blood transfusion for medical staff in western China.

Regulatory status and research progress in the supervision of cannabinoid compounds in food in some countries and regions / 上海预防医学

A group of compounds structurally related to tetrahydrocannabinol or capable of binding to cannabinoid receptors are collectively referred to as cannabinoids. Cannabinoids can be divided into plant derived cannabinoids， synthetic cannabinoids， and endogenous cannabinoids. Δ-9-THC is the only psychoactive compound in plant cannabinoids. Cannabis with Δ-9-THC>0.3% is internationally listed as a prohibited drug， while cannabis with Δ-9-THC<0.3% is industrial cannabis. Due to its low addiction and high commercial value， it is allowed to be added to food in many countries. More and more industrial cannabis foods become popular， and the detection/analysis of cannabinoid compounds in cannabis foods is particularly important； In addition to industrial cannabis， which is widely used in food， there are also various new drugs， synthetic cannabinoids， disguised as conventional food， which can cause the social problems and increase the food safety risks. This article will elaborate on the regulatory status of cannabinoid compounds in food， In order to promote the safety supervision of the domestic cannabis food.

Discussion on Development Status of Traditional Chinese Medicine Dispensing Granules and Survival Strategy of Enterprises / 中国实验方剂学杂志

As an important complementary form of decoction pieces of traditional Chinese medicine（TCM）， TCM dispensing granules has the advantages of being free of decoction， easy to take， easy to carry and easy to be dispensed， which greatly improves the capacity of emergency services of TCM and is more in line with the needs of modern society. With the end of the pilot project of TCM dispensing granules， the market has been fully liberalized， the competition has been intensified， and it is in the transition period of switching between the new standard and the old one， and there are some problems such as the shortage of varieties， the change of specifications and the difference of quality， and the production enterprises are facing new opportunities and challenges. Based on this， the authors intend to systematically sort out the policies and regulations， enterprise layout and standard formulation since the pilot of TCM dispensing granules. In view of the problems in the post-pilot stage and from the perspective of survival and development of enterprises， it is suggested that enterprises should establish a quality control system for the whole industry chain of TCM dispensing granules to reduce process costs and increase enterprise competitiveness， further increase the investment in scientific research， overcome the key technical problems of difficult varieties， actively and orderly promote the research of national standards， in order to ensure the integrity of clinical formula varieties， and establish and improve the efficacy evaluation mechanism of TCM dispensing granules， build a consistency evaluation system between TCM dispensing granules and decoction pieces. Government departments should strengthen the guidance， fully mobilize the enthusiasm of scientific research institutions， enterprises and hospitals， and explore the establishment of "government-industry-study-research-application" mode to promote the development of TCM dispensing granule industry.

Aflatoxin Occurrence, Food Regulations, Dietary Exposure, and Risk Assessment: A Mini Review from the Malaysian Perspective

@#Aflatoxins are ubiquitous and occur in food. Exposure to aflatoxins seriously impact the health of human and animal. It is concerning especially when aflatoxins are odourless, colourless, and tasteless that hardly be detected through naked eyes. Ingestion of aflatoxin-contaminated food contributes the major route of exposure. The present review is an update on the aflatoxin occurrence in food, aflatoxin regulations in food, and recent risk assessment of aflatoxin exposure in Malaysia. Peanuts and chili were more prone to aflatoxin contamination in Malaysia. The extreme weather experienced in Malaysia and global climatic change may worsen the aflatoxin contamination in food. The regulatory standards for aflatoxins imposed by Malaysia are less stringent than developed countries. The dietary exposure of aflatoxins among Malaysian was relatively high as compared with other Asia countries, ranging from 0.002 to 34.00 ng/kg body weight/day. Nonetheless, Malaysian population had low risk of aflatoxin-related liver cancer, with an estimated liver cancer risk of <1 cancer case/100,000 population/year.

Conformance of the Food Vendor Carts Design to the Prescribed Standards as per Food Safety and Standards Regulations: Assessment from an Urban Area of North India

Background: Food Safety and Standards Authority of India, established under the Food Safety and Standards Act, 2006, is mandated with disseminating evidence-based standards, regulating the manufacture, storage, distribution, sale, and import of street food, for ensuring the availability of safe and wholesome food for human consumption and matters connected in addition to that or incidental to that. Hence, this study was conducted to ascertain the conformance of the design of street food vendor’s carts to the prescribed standards. Methods: We conducted a cross?sectional study in Chandigarh between July 2017 and March 2018 among 400 street food vendors. The primary dependent variable of the study was conformance. The carts were evaluated for their conformance to the standard recommended design based upon a checklist designed using the guidelines of Food Safety and Standards Regulations, 2011. Results: Almost half of the respondents had an experience of 6–15 years (48.5%) and were earning between Rs. 500 and 1000/day (56.3%). The majority of them (95%) were migrants from other states. Only 26.3% were using mobile vending sites. On regression analysis, better cart score was predicted by age, education, increasing experience, higher income, when food was prepared at home only, and with assistance in the form of helpers. Conclusions: This study indicates that although the policy was formulated 8 years back, the standards of street food carts were still below par in Chandigarh. The government should give technical specifications and ensure uniformity at the national level.